Sited 200 metres from Barcelona Cathedral, the Regencia Colón is a six storey Gothic Quarter hotel, 500 metres from both Plaza Catalunya and the harbour and one kilometre from the Museum of Modern Art.

The 52 guestrooms feature light wooden floors, floral patterned bedspreads and wooden headboards. All are equipped with satellite TV, Internet connections, safes, minibars, and bathrooms with shower/tub combinations and bidets.

The simply furnished restaurant serves a buffet of Spanish and international dishes for breakfast and lunch. Traditional Spanish and Mediterranean dishes are served for dinner at the Regencia Colón's sister hotel, the Hotel Colón, 80 metres away. Guests can relax with a selection of beers, wines and cocktails in the early 1900s style lobby bar, which features upholstered chairs, flowers and oil paintings. Staff at the 24-hour front desk can safeguard valuables, exchange currency and arrange dry cleaning services. A concierge service is available to help guests plan excursions, and those arriving by car also have access to the hotel's parking (surcharge). The hotel is located 500 metres from the cafés, market stalls and street performers of Las Ramblas, while the distinctive Gothic Cathedral is 200 metres south. Those who prefer shopping will find an abundance of fashionable shops on the surrounding side streets and Portal de l'Angel, 350 metres away.

Barcelona International Airport is ten kilometres away, with an approximate driving time of 20 minutes.