Named after San Francisco's most renowned literary icon, the Hotel Mark Twain in San Francisco, California, is positioned within two blocks of Union Square's high end shopping and one half mile from the Yerba Buena Center for the Arts. The property is five blocks from the Moscone Convention Center and the San Francisco Museum of Modern Art. For outings around the city, a BART stop is located three blocks away.

Sultan, the hotel's restaurant, hosts American style cuisine for breakfast and an Indian and Pakistani influenced menu for lunch and dinner.

Business friendly amenities include meeting rooms, exhibit space and business services. high speed Internet access in the lobby and for wireless Internet access which is available at several stations for a fee. For recreation, the Hotel Mark Twain boasts an impressive fitness center where treadmills, universal weights and a stationary bike and are accessible around the clock.

Cable cars stop two blocks from the hotel, giving guests convenient access to Fisherman's Wharf, Chinatown and many of San Francisco's most celebrated attractions.