The Hotel Gambrinus is located in the historic district of Rome, Italy. The hotel is 600 meters from the Via Veneto thoroughfare and less than two kilometers from some of the Spanish Steps, the Trevi Fountain and Piazza Navona. Termini station is 800 meters from the hotel. The Capitoline Museums are in Piazza del Campidoglio, less than two kilometers from the hotel. A bronze cast of a Roman gladiator's armor stands watch in the lobby of the Hotel Gambrinus. The hotel offers currency exchange and concierge services.

Complimentary buffet breakfasts are served each morning in the Gambrinus Restaurant.

Wireless Internet access is available through hotel computers in the restaurant.

The 57 guestrooms in the Hotel Gambrinus are decorated with parquet floors and green, gold, red, yellow and cream color schemes. The private bathrooms feature marble sinks. First floor rooms include balconies and select rooms face the courtyard of Napolean's villa, adjacent to the hotel.

Internet access is available in the guestrooms for a fee. The Hotel Gambrinus provides a complimentary bottle of wine for guests upon arrival.