The St. Regis Grand Hotel is characterised by late nineteenth century Belle Epoque design; renovated in 1999, the hotel's interior is decked with crystal, frescoes, soaring ceilings, sculpted columns, and precious antiques. The hotel is located in the centre of Rome, two kilometres from the Trevi Fountain and the Spanish Steps.

The 161 guestrooms are decorated in red, cream and gold with frescoes, Murano chandeliers, antique furniture, and marble bathrooms with Hermes toiletries, bathrobes and slippers. Modern amenities include air conditioning, Internet connections, satellite television with pay movies, minibars, and safes.

Guests can choose from two dining options: The internationally renowned Vivendo serves creative Mediterranean dishes along with an extensive wine list in a stylish, formal setting. Le Grand Bar, decorated in black marble and red velvet offers light refreshments including afternoon tea, and a range of speciality cocktails. The Caroli Health Club houses a staffed, mirrored fitness centre and a wellness centre with men's and women's saunas; two treatment rooms supply a range of massage services.

Those on business can make use of the hotel's 15 meeting spaces and fully equipped business centre, and guests arriving by car will find pay parking onsite. Further amenities include personal shoppers, a 24-hour butler service, laundry facilities and a 24-hour multilingual concierge service on hand to assist with sightseeing needs.

Nearby attractions include the Forum, Capitoline Hill, Galleria Borghese and Via Condotti shopping street, which are all within two kilometres of the hotel. The Pantheon and Coliseum are within three kilometres and the Vatican City is at a five kilometre distance.

Rome Fiumicino Airport is 26 kilometres away.