A small, modern townhouse hotel, the Hotel Quisisana is centrally located 100 metres from Termini station and within a kilometre of Piazza Venezia.

The 40 contemporary guestrooms are decorated in sunset and brown hued earth tones with coordinated fabrics. All are equipped with satellite television, direct dial telephones, minibars and bathrooms with tubs, handheld showers and robes. Guests can relax in the hotel's bar and lounge, and peruse complimentary newspapers in the lobby over coffee. Bistro Quisisana serves a range of fine wines, accompanied by specially selected snacks, including cheeses, mushrooms and cold meats. The bistro offers wine tasting sessions in an intimate atmosphere, with soft lighting, long drapes, Murano glass and marbled surfaces. Sightseeing itineraries can be planned via public Internet access, while multilingual staff on the 24 hour front desk can answer tourist enquiries and book excursions including visits to the Vatican, complete with a Papal audience.

Business travellers can avail themselves of a range of office support services and a conference room seating up to 30 people.

Visitors arriving by car will find parking available on site, and airport transfers can be arranged on request (surcharge).

Many of Rome's most popular attractions are close at hand, with the Santa Maria Maggiore church and the shops of Via Nazionale sited within 200 metres. Piazza Venezia and the Trevi Fountain are both within a kilometre of the hotel, and the Vatican is two kilometres away.

Rome Fiumicino Airport is 35 kilometres away, with an approximate driving time of 45 minutes.