A former 19th century aristocrat's townhouse, Hotel Seiler is located in central Rome, Italy, within 500 metres of the Via Veneto and Quirinale Palace. The hotel is 800 metres from the Trevi Fountain, 900 metres from the Spanish Steps, and one kilometre from the iconic Colosseum.

The Hotel Seiler's dining room serves complimentary continental breakfast amid its exposed brickwork, arches and hand painted murals of Rome.

There are numerous restaurants near the hotel.Guests can use a nearby fitness centre at a reduced rate. The concierge at the 24 hour front desk can plan tours and sightseeing itineraries, and book tables at the nearby trattoria. Other available services include currency exchange, dry cleaning and luggage storage.

Hotel Seiler's 33 modern guestrooms are decorated in light tones with wood panelling, patterned fabrics and framed prints. All rooms have televisions, refrigerators and direct dial phones. Some rooms feature original frescoed ceilings.