The Hotel Dona Palace is 50 meters from St. Mark's Square in Venice, Italy. Basilica di San Marco, Campanile bell tower and Palazzo Dulcale are also 50 meters from the hotel. Less than 350 meters away are the Palazzo Ducale, the Grand Canal and Rialto Bridge.

Venice Marco Polo Airport is 13 kilometers from the hotel.

Water taxis run from the airport to San Marco Square. Dating to the 15th century, the Hotel Dona Palace is a Gothic style property built by a Venetian noble family. The hotel features fresh flowers in a marble floored lobby where drawings of medieval Venice are displayed. Complimentary newspapers are provided in the hotel's second story lounge. Complimentary American style buffet breakfasts are served each morning. The Cocktail Bar features the building's original ceiling and Byzantine arches with views of the side canal. The bar serves snacks and beverages inside or in the garden courtyard. The courtyard is furnished with teak tables and rattan chairs.

The hotel owner's three restaurants are within 25 meters. Hotel guests are offered 15% discounts. Complimentary Internet access is available in the hotel's public areas.

The five story Hotel Dona Palace's 27 guestrooms feature 19th century Biedermeier style furniture with high ceilings and tufted leather headboards. In room safes are provided. Bathrooms feature black granite and makeup mirrors. Complimentary wireless Internet access is available. Two terraces and a private courtyard provide vantage points from which to view the city.