A modern building overlooking the Nile, the Pyramisa Cairo is in the business district, 10 kilometres from Khan el Khalili Bazaar.

The 200 air conditioned suites feature peach decor with dark wood furniture and all have balconies and separate living areas with dining tables and lounges. Modern amenities include satellite television, direct dial phones, high speed Internet ports, safes, and minibars. Guests can enjoy music, dancing, and live entertainment at the Galaxy nightclub, or try their luck with roulette, black jack, poker and more at the gaming tables of the Casino D'Egypte. A sauna, steam room and outdoor pool are on hand for relaxation, and massages and beauty treatments are also available.

Dining options include Turkish, Italian, Mexican and traditional Egyptian dishes, or guests can enjoy a drink in the English style pub. Practical amenities at the hotel include currency exchange and free parking and there are three banqueting halls available for conferences and functions. There is a gift shop for newspapers, postcards and souvenirs and staff at the 24 hour front desk can advise on local sightseeing opportunities. The Egyptian museum is five kilometres away and the Museum of Islamic Art and Coptic Museum are both within 10 kilometres. The Pyramids and Sphinx, with their nightly sound and light show, are 25 kilometres from the hotel.

Cairo International Airport is 20 kilometres away with an approximate driving time of 45 minutes.