On a quiet street one block from the River Tiber, the contemporary Hotel dei Mellini is housed behind a pristine 18th century neoclassical faτade, formerly two apartment buildings.

The 80 air conditioned guestrooms are decorated in soft neutral shades of taupe and brown with heavy striped drapes, cream upholstery, coordinating patterned bedspreads, and cherry wood furniture. All have minibars, safes, direct dial phones, high speed Internet connections (surcharge), slippers, and satellite television with pay movies. Marble bathrooms include telephones, bidets, bathrobes, and Etro designer toiletries.

Guests can enjoy drinks and snacks on the sunny roof terrace with its canvas awnings, potted lemon trees, climbing greenery and flowering planters. For sun worshippers there is also an adjoining solarium with loungers and a shower. Off the white marble lobby on the ground floor there is a quiet lounge, a bar, and a cool central patio with tables, seating and large potted palms. Buffet breakfast is served daily in the breakfast room and the bar offers an all day menu of light hot and cold dishes. The hotel houses a fine contemporary Italian art collection with works displayed throughout the public areas, many of which are available for sale.

For business guests there are three conference rooms; audio visual equipment available includes video conferencing and computer rental. Parking in the hotel's garage costs 25 EUR per night. In the surrounding streets guests will find many boutiques and cafés including a tempting choice of cake and chocolate shops, and visitors are just across the river from many of the city's sights the Spanish Steps, Pantheon, and Villa Borghese are all within one kilometre. The Vatican is two kilometres and the Coliseum is three kilometres away.

The nearest metro station is Lepanto (800 metres) and Rome Fiumicino Airport (FCO) is 35 minutes and 33 kilometres drive from the hotel.