The Madison Hotel Hamburg is located in a contemporary building with a glass fronted lobby in the centre of the city of Hamburg. The 166 apartments over six floors have light pastel décor, stylish furnishings including desks, fully equipped kitchenettes and balconies. All are equipped with Internet connections (surcharge), cable television, direct dial multi line phones with voicemail and VCRs. Other amenities include air conditioning, coffee and tea makers and complimentary newspapers. Bathrobes, complimentary toiletries, hair dryers and makeup mirrors are also all provided.

Public areas area air conditioned and complimentary newspaper are available in the lobby. Multilingual staff at the 24-hour front desk can offer currency exchange and tour assistance. Guests (from 12 years on) can enjoy the fitness and spa facilities of the Meridian Spa (located in the same building) for a discount.

There is a business centre and four meeting rooms with a capacity of up to 115 people and audio visual equipment is available.

Marleys Restaurant features Mediterranean style décor and serves international cuisine with inspiration from California while Charleys Bar has a lounge bar style and red décor. Hamburg's harbour is one kilometre from the hotel and the lively nightlife of the Reeperbahn is two kilometres away.

Hamburg's main railway station is three kilometres from the hotel and Hamburg Fuhlsbⁿttel Airport is 14 kilometres away, an approximate driving time of 25 minutes.