Previously the residence of a nobleman and patron of the arts, the Hotel ca Vendramin di Santa Fosca is housed in a lavishly decorated, traditional canal side building in the Santa Fosca district in Canareggio, one kilometre from the famous St. Mark's Square.

The hotel's air conditioned 11 guestrooms have classical style décor and suites are individually decorated with original frescos, exposed beams, parquet flooring, soft tone bedside lamps and chandeliers.

All rooms also provide satellite television, minibars, safes, Internet ports and ensuite bathrooms with slippers and hair dryers.

Breakfast is served every morning in the morning room and guests have a choice of English style or continental. Guests also enjoy drinks and beverages at the hotel's bar while there is a traditionally decorated hall where guests can relax or access the Internet for free. Fax services are available at reception and the 24-hour front desk has multilingual staff that can recommend good places to eat as well as interesting places to visit, lend assistance with transport arrangements and other bookings. The hotel itself has an interesting history and has housed many notable Venetians including its namesake, details of whom can be discovered during one's stay.

The hotel is located within 200 metres of a casino and restaurants are also located within 200 metres of the hotel. Within 300 metres is the Palazzo Albrizzi and within 400 metres is the Jewish Ghetto. The Rialto Bridge is 600 metres from the hotel and the infamous St.Mark's Square is one kilometre from the hotel.

Marco Polo Airport is 20 kilometres (12 miles) from the hotel.