Hotel Spagna is across the street from the Santa Lucia Railway Station, connecting visitors throughout the town of Venice, Italy. The Jewish Ghetto is 500 metres from this hotel and the Piazza San Marco is two kilometers away. The hotel provides fax services and safe deposit boxes at the 24 hour front desk.

The 19 guestrooms at the Hotel Spagna include cable television and wired Internet access. Minibars and safes are also provided in each room.