Situated in the centre of historical Florence, the exclusive, recently refurbished 18th century palace hotel, Relais Santa Croce, is 12 kilometres from the airport.

This 3 floor hotel has 24 individually styled guestrooms and suites with minimalist decor, antique furniture and leather upholstery. All rooms include walk in closets and are equipped with complimentary high speed Internet connected to satellite plasma television with pay movies, direct dial phones, safes and minibars. Some of the marble and quartzite bathrooms feature steam or spa baths and televisions while all have phones and complimentary toiletries. After exploring the historically rich centre of Florence, guests can relax with a cocktail beneath the original fresco ceilings in the classically furnished salon, music room or cigar lounge. Weary travellers can unwind in the sauna or steam room or can relax with a massage; while more energetic guests can take advantage of discounted use of the nearby fitness centre.

For those seeking exclusive fine dining, the three Michelin star Enoteca Pinchiorri restaurant is located on the hotel's ground floor. Guests with cars can utilise the parking garage (surcharge); while a limousine service is also available. For further cultural experiences, multilingual staff at the 24 hour reception can book tickets for theatre and concerts.

Nearby attractions include the Uffizi art gallery, 500 metres away and the family home of Michelangelo, Buonarroti house, which is 700 metres away.

Amerigo Vespucci Airport is 12 kilometres from the hotel.