The Rocco Forte Hotel de Rome is housed in an early 19th century building which was a bank until 1945 and features traditional architecture with high ceilings and stucco moulding; the hotel is located in central Berlin, 500 metres from the Brandenburg Gate.

Franzoesische Strasse metro station is 400 metres from the hotel and Berlin Tegel Airport is 11 kilometres away, an approximate driving time of 20 minutes. The hotel has an indoor swimming pool and spa facilities include a spa tub, a sauna and massage treatments with beauty treatments also available. There is a gym with fitness equipment, and Pilates, yoga and aerobics sessions are available on request. Multilingual staff at the 24 hour front desk can offer currency exchange, express check in and check out and tour assistance.

High speed wireless Internet access (surcharge) is available in the air conditioned public areas and there is a business centre.

Restaurant Hotel de Rome serves Mediterranean cuisine and features contemporary furnishings, live music five nights a week and a terrace for outdoor dining in summer. The Hotel de Rome Bar & Lounge offers a wide range of drinks and cocktails as well as snacks in a room overlooking the inner courtyard.

Rocco Forte Hotel de Rome offers 146 guestrooms located on five floors, all of which combine stuccoed ceilings with contemporary furnishings and decor and include satellite television, wired and wireless Internet connections, safes, and minibars. Bathrooms include robes and designer toiletries. Guests can get a flavour of what Berlin was like when it was divided by the Wall at the Checkpoint Charlie Museum 800 metres from the hotel.