Hotel Diocleziano is located in the old heart of Rome, Italy and is 50 meters from the Roman baths Terme di Diocleziano. The shopping street Via Nazionale is 500 meters from the hotel, while the former royal residence, the Quirinale, and Via Vittorio Veneto are both one kilometer from the hotel. Termini rail and metro stations are both 100 meters away.

Rome Fiumicino Airport is 30 kilometers from the hotel. A modern hotel occupying a 19th century building on Esquilino Hill, Hotel Diocleziano offers complimentary newspapers in the air conditioned lobby. Multilingual staff on the 24 hour front desk provides safe deposit boxes or reservations for city tours. Complimentary American breakfasts are served each morning.

The five story Hotel Diocleziano's 35 guestrooms are decorated in warm brown and orange tones with cherry wood furniture.

Amenities in all of the guestrooms include minibars and complimentary newspapers.

The guestrooms all have private bathrooms. High speed Internet access is available in the rooms for a fee. The Diocletian Baths were the biggest thermal baths in the world. Nowadays they host a collection of funereal art works, such as sarcophagi, and decorations dating back to the Aurelian period. Octagonal Hall offers free admission.