The Hotel Villa San Pio is in Rome, Italy less than one kilometer from Roman landmarks including the Coliseum and Caracalla Thermal Baths. Vatican City and the Trevi Fountain are within five kilometers from the hotel.

Rome Fiumicino Airport is 30 kilometers away. An archetype of classic Italian villas, the Hotel Villa San Pio's lobby features checkerboard patterned marble floors and marble columns. Hotel amenities include a multilingual staff at a 24 hour front desk and complimentary newspapers in the lobby. Complimentary parking is available on the property. Complimentary buffet breakfasts are served each morning.

Il Giardino De Gli Aranci restaurant serves Mediterranean menus for dinners and features a garden and gazebo. Wireless Internet access is available in public areas. The hotel is surrounded by a beautiful garden.

The 78 guestrooms, over three floors in the Hotel Villa San Pio carry through the Italian villa style in the high ceilings, the area carpets on the tiled floors and the furniture. Room amenities include minibars and private bathrooms with shower/tub combinations. Internet connections are available for a fee. Some rooms offer views of the private garden. After seeing the Baths of Caracalla, 600 meters from the hotel, cross Viale Aventino, then south past the Priorato di Malta, is one of several buildings in the city belonging to the Knights of Malta, which has a celebrated view of the dome of St Peter's through the keyhole of its main gate.