Occupying a private villa dating back to 1910, the Hotel Villa San Lorenzo is located in the fashionable San Lorenzo district, two kilometres from the Coliseum and the Roman Forum.

The 39 guestrooms feature traditional decor with antique style furniture, complementing the villa's original features. All open onto balconies and include cable television, wireless Internet connections, direct dial phones and safes. Bathrooms include showers and bidets. After breakfast, guests can relax in the tranquil courtyard garden and browse the newspapers. The hotel bar maintains the villa's period atmosphere and is open throughout the day. Those with laptops can get online via wireless Internet access, and multilingual staff at the 24 hour front desk can advise on sightseeing opportunities in the area. Complimentary secure parking facilities are available on site.

The area around the hotel offers many shops and restaurants, and the Piazza di Porta Maggiore is 300 metres away. The Coliseum and the Roman Forum are both within two kilometres, the Piazza Venezia and Trevi Fountain are three kilometres from the hotel, and Piazza Navona is four kilometres away.

Rome Fiumicino Airport is 35 kilometres away, with an approximate driving time of 40 minutes.